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The only exception is an added double bond at the carbon 1 and 2 positions, which is why equipoise is less androgenic and less estrogenic than testosterone. In other words, an estrogenic androgen or an aromatase inhibitor is a much safer option for those who do not want to use testosterone and should be used with caution or only used for those with a very short test or who have limited testicular capacity. There are no estrogenic androgens in the body, so even an estrogenic androgen like levonorgestrel, dienogest, is likely to be less dangerous (and less side effects) than a more dangerous androgen like Teflon and E2. How it Works Estradiol works by binding to androgen receptors and then taking them away. It binds to androgen receptors in the prostate, androgen receptors in breast tissue, androgen receptors in peripheral androgen systems, androgen receptors on the thyroid, androgen receptors on the hypothalamus, in the testes, in adrenal glands, and in adipose tissues of the body. When a receptor is stimulated by a hormone, it releases a hormone - usually an enzyme called aromatase. At first, the enzyme doesn't work very well. When you take the hormone, the enzyme breaks it down and releases a new, slightly less active version of it. The new enzyme will then release estrogen, and your body will start making more. But it only takes one minute for the new aromatase enzyme to break it down. Some androgen-sensitive women have low levels of androgen receptors. When taking estrogen or androgen-releasing hormones, an enzyme called aromatase is in the body, and sometimes the new estrogen made doesn't behave as well in the body as the original. The new hormone, the estrogen, doesn't work as well, and you have less testosterone and more estrogen in your body. If you take an androgen-releasing hormone and an injectable estrogen (like a progestin), then you only have the low level of androgen receptors, which may not allow a person to make the estrogen as well as they might otherwise. This is similar to the situation with lower estrogen and high levels of estrogen. When you do get a higher estrogen level, the new production can then become less effective and cause the levels to drop significantly, which can result in poor libido and loss of sexual interest. When you take an estrogen and an injectable progestin, the levels of hormones do not interact as well, which may allow a person to produce more estrogen and still get the desired effects. The fact that all Similar articles: